- Hostile Takeover: Leukemia Cells Alter Composition and Homeostatic Function of the Bone Marrow NicheFebruary 01, 2014 | Shelton Viola, MD | Peter Kurre, MD
Drs. Viola and Kurre review a study that describes an active process in which reprogramming of niche components by neoplastic cells favors leukemic proliferation while compromising normal hematopoiesis.
- Ironing Out the Problem: Targeting Hepcidin to Treat the Anemia of InflammationFebruary 01, 2014 | Charles T. Quinn, MD, MS
Dr. Charles Quinn reviews a recent study that provides cautions optimism for development of both a reliable and broadly available clinical test for quantifying hepcidin concentration and a targeted therapy for anemia of inflammation.
- MLL Fusions Sustain Leukemia Through NFĸBFebruary 01, 2014 | Pamela S. Becker, MD, PhD
Dr. Becker reviews new research that demonstrate that NFĸB signaling is critical for propagation and maintenance of MLL-associated leukemias and for implementation of the epigenetic programs directed by the MLL fusion proteins.
- Stabilizing a Mutant Enzyme: A Potential Therapeutic Strategy for Günther DiseaseFebruary 01, 2014 | Gregory M. Vercellotti, MD
Dr. Gregory Vercellotti reviews a paper that emphasizes the importance of determining the mechanism by which a genetic abnormality causes disease.
- Take Me to the Liver: New Insights on Antibody MechanismsFebruary 01, 2014 | Peter Johnson, MD
Dr. Peter Johnson reviews a recent study that has implications for the use of antibodies in the clinic and may provide an explanation for the preferential effect of anti-CD20 therapy on circulating B cells as opposed to those in lymphoid or other organs, where the process of depletion is less rapid.
- The Hemostatic Mechanism and AllergyFebruary 01, 2014 | Pete Lollar, MD
Dr. Pete Lollar reviews new findings that support a model in which airway proteinase activity, possibly primarily mediated by thrombin, leads to formation of fibrin and/or fibrin degradation products that are ligands for TLR4.