Three Identical Strangers, One Pressing Question
Dr. Kristen O'Dwyer discusses "Three Identical Strangers," a documentary film about triplet boys born to a single mother and adopted by three separate families, who later l
RNA Isoforms, Innate Immunity, and Leukemogenesis: IRAK4 As a Novel Therapeutic Target in MDS/AML
Drs. Brierley and Mead discuss a study that identified a poor-prognosis subtype of MDS/AML defined by the accumulation of certain mRNA isoform changes in innate immune path
Dr. Taylor and Dr. Abdel-Wahab look back at studies from 2018 that show great progress in therapies for myelodysplastic syndromes.
Dr. Abdel-Wahab and Dr. Taylor look at a study that evaluates the safety of combining the anti-PD-L1 antibody atezolizumab with the novel hypomethylating agent guadecitabine in older adults with AML not eligible for standard induction therapy.
Dr. Abdel-Wahab and Dr. Taylor review the progress made during 2016 in understanding the molecular underpinnings of acute myeloid leukemia (AML) as well as in the use of precision medicine for patients with AML.
Dr. Abdel-Wahab and Dr. Taylor study the biology of mutant IDH1 in a myeloid-specific context with the additive effect of aging, and highlight one of the TET2-independent consequences of 2HG.
Dr. Abdel-Wahab and Dr. Taylor cover a study that measures the safety of combination ABT-199 and hypomethylating agents in older adults with acute myelogenous leukemia (AML), who are treatment-naive and not eligible for standard induction therapy.
Drs. Abdel-Wahab and Taylor look at a study about the use of core circadian clock genes in anti-leukemic therapy.
Dr. Abdel-Wahab and Dr. Taylor shed light on two recent studies that have identified synthetic lethal interactions created by deletion of genes in the neighboring genome around the 9p21 locus. Deletion of the 9p21 locus is one of the most common genetic events in cancer, yet there is no therapy that targets cancer cells with this alteration.
Drs. Abdel-Wahab and Taylor look at several studies that have provided a set of techniques, tools, and knockout cells, which can help provide insight into new functions of our genome and new therapies to target cancer.
May-June 2019Volume 16, Issue 3
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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