Immune hemolytic anemias can occur as isolated conditions or in
association with a variety of systemic illnesses (particularly
rheumatic conditions, infections, and various neoplasms), or can be
induced by certain medications. These conditions can produce
life-threatening anemia; prompt diagnosis and treatment are essential.
- Describe the pathophysiology and site of red blood cell
destruction of immune-mediated hemolysis due to IgG, IgM, and
- Describe the procedures involved in
performing a direct antiglobulin test (direct Coombs test) and an
indirect antiglobulin test (indirect Coombs test).
- List mechanisms by which drugs induce immune hemolytic anemia.
warm antibody-induced autoimmune hemolytic anemia from cold
antibody-induced autoimmune hemolytic anemia on the basis of:
- Immunoglobulin class of the antibody
- Presence of red blood cell agglutination
- Direct antiglobulin test results
- Clinical manifestations
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