Stem cell transplantation is a treatment options for many patients
with hematologic diseases. Stem cell transplantation involves
eliminating a patient’s hematopoietic and immune system by chemotherapy
and radiotherapy and replacing it with one’s own or another person’s
hematopoietic stem cells.
- List the indications for hematopoietic stem cell transplant and the rationale for this treatment choice.
- Describe the different types and sources of hematopoietic stem cells.
- Describe principles of pre-transplant conditioning and the role for post-transplant immunosuppression.
- Describe graft versus host disease and graft versus tumor effect.
- Describe the pathophysiologic basis for acute and chronic graft versus host disease.
the changes in humoral and cellular immunity following stem cell
transplant and how they relate to infectious complications.
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