American Society of Hematology

Milestones in Antiplatelet Therapy

1882	Giulio Bizzozero describes blood platelets.
1953	Lawrence Craven reports that aspirin prevents heart attacks.
1960s	Harvey Weiss, Sir John Vane, Philip Majerus, Gerald Roth, and others elucidate the antiplatelet actions of aspirin.
1970s	Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation.
1994	Barry Coller’s monoclonal antibody to platelet GP IIb/IIIa is approved for use in coronary angioplasty.
1998	ADP receptor antagonists are shown to be effective antiplatelet agents in preventing coronary stent thrombosis.

"Antiplatelet Therapy" by Andrew I. Schafer, MD, and these accompanying milestones were published in December 2008 as part of the special ASH anniversary brochure, 50 Years in Hematology: Research That Revolutionized Patient Care.