Below you will find a collection of articles from Hematology, the ASH Education Program, written by experts in the field about a variety of bleeding disorders, including hemophilia, von Willebrand disease, platelet disorders, thrombocytopenia, and thrombocytosis. General information about bleeding disorders, as well as specific information on hemophilia and von Willebrand disease, can be found on this website. A number of links to organizations that inform and support patients with bleeding disorders and their families are also available.

General Information

• Biological Rationale for New Drugs in the Bleeding Disorders Pipeline (2011) 
• What To Do When You Suspect an Inherited Platelet Disorder (2011) 
• Understanding and Evaluating Platelet Function (2010) 
• Determinants of Platelet Number and Regulation of Thrombopoiesis (2009) 
• Drug-Induced Thrombocytopenia: Pathogenesis, Evaluation, and Management (2009) 
• Thrombocytosis (2009) 
• Factor XI Deficiency - Resolving the Enigma? (2009) 
• Does Helicobacter pylori Eradication Therapy Result in a Platelet Count Improvement in Adults with Immune Thrombocytopenic Purpura Regardless of H pylori Infection? (2008) 
• What Is the Evidence for the Off-label Use of Recombinant Factor VIIa (rFVIIa) in the Acute Reversal of Warfarin? (2008) 
• Thrombocytosis and Thrombosis (2007) 
• Novel Thrombopoietic Agents (2007) 
• Aspirin and Clopidogrel Resistance (2007) 
• Bleeding and Thrombosis Risks in Plasma Cell Dyscrasias (2007) 
• Management of Thrombohemorrhagic Syndromes (THS) in Hematologic Malignancies (2007) 
• Double Hazard of Thrombophilia and Bleeding in Leukemia (2007) 
• Platelets: Testing, Dosing and the Storage Lesion—Recent Advances (2006) 
• Perioperative Evaluation of Bleeding Diathesis (2006) 
• Bleeding Disorders in Premenopausal Women: (Another) Public Health Crisis for Hematology? (2006) 

Hemophilia and von Willebrand Disease

• Costs of Care in Hemophilia and Possible Implications of Health Care Reform (2011) 
• Current Controversies in the Formation and Treatment of Alloantibodies to Factor VIII in Congenital Hemophilia A (2011) 
• What is the Evidence for the Use of ImmunomodulatoryAgents to Eradicate Inhibitory Antibodies in Patients with Severe Hemophilia AWho Have Previously Failed to Respond to Immune Tolerance Induction? (2011)  
• The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues (2010) 
• Alternative Strategies for Gene Therapy of Hemophilia (2010) 
• Hemophilia: New Protein Therapeutics (2010) 
• Low von Willebrand Factor: Sometimes a Risk Factor and Sometimes a Disease (2009) 
• Optimizing Treatment of von Willebrand Disease by Using Phenotypic and Molecular Data (2009) 
• Update on Progress and Hurdles in Novel Genetic Therapies for Hemophilia (2007) 
• Bleeding Disorders in Premenopausal Women: (Another) Public Health Crisis for Hematology? (2006) 

Platelet Disorders

• Acquired Disorders of Platelet Function (2011) 
• What To Do When You Suspect an Inherited Platelet Disorder (2011)  
• Bleeding Disorders in Premenopausal Women: (Another) Public Health Crisis for Hematology? (2006) 
• Management of Bleeding Disorders in Children (2005) 

Thrombocytopenia

• Diagnosis and Management of Immune Thrombocytopenia in the Era of Thrombopoietin Mimetics (2011) 
• Thrombocytopenia in the Intensive Care Unit Patient (2010) 
• Immune Thrombocytopenia (2010) 
• Evidence-Based Mini-Review: Is Indium-Labeled Autologous Platelet Scanning Predictive of Response to Splenectomy in Patients With Chronic Immune Thrombocytopenia? (2010) 
• Thrombocytopenia in Pregnancy (2010) 
• Viral-Associated Immune Thrombocytopenic Purpura (2008) 
• Helicobacter pylori and Chronic ITP (2008) 
• TTP and ADAMTS13: When Is Testing Appropriate? (2007) 
• Immune Thrombocytopenic Purpura of Childhood (2006) 
• Think of HIT (2006) 
• Inherited Platelet Disorders (2005) 

Thrombocytosis

• Thrombocytosis (2009) 
• Thrombocytosis and Thrombosis (2007) 

back to top