(WASHINGTON) – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, and Deputy Editor Nancy Berliner, MD. If you would like a PDF copy of any of the manuscripts highlighted below or would like to request an interview with the author, please email firstname.lastname@example.org
PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement, Khan et al.
In this week’s issue of Blood, Khan and colleagues retrospectively evaluate the clinical implications of marrow involvement identified by positron emission tomography – computed tomography (PET-CT) and iliac crest biopsy in patients with diffuse large B-cell lymphoma (DLBCL). Of 130 patients, 35 (27 %) had marrow involvement; 33 were identified by PET-CT compared to 14 by marrow histology. Investigators observed that PET-CT scan identified all clinically important marrow lymphoma, while marrow biopsy did not up-stage any patient, demonstrating that PET-CT has a high level of sensitivity and accuracy for identifying marrow disease in DLBCL. The authors suggest that routine marrow biopsy may no longer be necessary for patients staged by PET-CT. These data from a single center confirm that in experienced hands, PET-CT has a high level of accuracy for assessing marrow disease in DLBCL.
Adenosine production by human B cells and B cell-mediated suppression of activated T cells, Saze et al.
The immunoregulatory role of adenosine (hydrolized from exogenous ATP) by CD39 and CD73 has recently attracted significant attention. This week in Blood, Saze and colleagues show that human peripheral blood B cells express functionally active CD39 and CD73, offering an intriguing paradigm for B cells in which ectoenzymes generate immunosuppressive AMP and adenosine. The widespread expression of CD39 and CD73 on human B cells is unexpected and differs from what is known from murine studies. This work establishes a new mechanism for regulatory B-cell activity and identifies adenosine as a mediator of immune suppression. The discovery that most B cells are capable of generating adenosine is important for the participation of B cells as regulators of T-cell responses.
Diabetes is associated with post-translational modifications in plasminogen resulting in reduced plasmin generation and enzyme specific activity, Ajjan et al.
Diabetes is associated with hypofibrinolysis by mechanisms that are only partially understood. In this week’s issue of Blood, Ajjan and colleagues describe an antifibrinolytic mechanism associated with glycation of plasminogen in patients with type 1 diabetes. Their results indicate that glycation of plasminogen in vivo leads to decreased fibrinolysis through reduced plasmin generation, reduced protein proteolytic activity, and reduced plasminogen-fibrin interactions. This study advances our knowledge on prothrombotic mechanisms that might be implicated in increased risk of thromboembolic events for diabetes patients. These changes are reversible with modest improvement in glycemic control.
Blood, the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH), the world’s largest professional society concerned with the causes and treatment of blood disorders.
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