(WASHINGTON) – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, and Deputy Editor Nancy Berliner, MD. If you would like a PDF copy of any of the manuscripts highlighted below or would like to request an interview with the author, please email email@example.com.
Extracellular protein disulfide isomerase regulates ligand binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation Hahm et al.
In this week’s Plenary Paper, Hahm and colleagues report that protein disulfide isomerase (PDI) regulates migration and adhesion of neutrophils at sites of inflammation. PDI is an enzyme primarily found in the endoplasmic reticulum where it helps to modify thiol-disulfide bonds and is also found on the cell surface where it is thought to catalyze isomerization or reduction of disulfide bonds. Using conditional knockout mice, investigators demonstrate that PDI-null neutrophils display defective Mac-1 dependent adhesion and crawling in response to TNF-induced inflammation. This discovery suggests that inhibition of PDI might offer a novel therapeutic target to suppress inflammation by interfering with neutrophil function.
Risk factors for first venous thromboembolism around pregnancy: a population based cohort study from the United Kingdom Sultan et al.
In this week’s issue of Blood, Sultan and colleagues examine risk factors for pregnancy-associated venous thromboembolism (VTE), collecting VTE incidence data from nearly 400,000 pregnancies in women between 1995 and 2009. Data from the population-based study show that the leading risk factors for antepartum VTE were varicose veins, inflammatory bowel disease, urinary tract infection, and pre-existing diabetes, while the leading risk factor for postpartum VTE was stillbirth. Other risk factors included medical co-morbidities, hemorrhage, preterm delivery, and caesarian section. Results from this study may identify new VTE risk factors in pregnancy beyond recognized thrombophilia for which thromboprophylaxis should be considered.
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1 Andolfo et al.
Dehydrated hereditary stomatocytosis, also known as hereditary xerocytosis (HX), is an autosomal dominant disease associated with hemolytic anemia with a cellular cation leak. It can also be associated with pre- and/or perinatal edema or with pseudohyperkalemia and effusions. In this week’s issue of Blood, Andolfo and colleagues report the results of their whole-exome-sequence analysis and subsequent identification of PIEZO1 as the gene responsible for HX. The PIEZO1 protein is expressed in the erythrocyte plasma membrane and in the liver and alters cation transport. Because the mutations leading to HX are pleiotropic, the authors suggest that the degree to which they impact cation transport can serve as an accurate predictor of future development of edema and effusion
Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.
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