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Information on How the New ESA REMS Program Will Affect MDS Patients
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March 11, 2010
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On March 24, the Food and Drug Administration (FDA) will require that all drugs called erythropoiesis-stimulating agents (ESAs) be prescribed and used under a risk management program, known as a risk evaluation and mitigation strategy (REMS), to ensure the safe use of these drugs.
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Persons With Quebec Platelet Disorder Have a Tandem Duplication of PLAU
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March 8, 2010
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Quebec platelet disorder (QPD) is an autosomal dominant bleedingdisorder linked to a region on chromosome 10 that includes
PLAU, the urokinase plasminogen activator gene. QPD increases
urokinase plasminogen activator mRNA levels, particularly during
megakaryocyte differentiation, without altering expression of
flanking genes.
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Medicare Physician Payment Cut Averted Through March 2010
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March 2, 2010
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The 21 percent Medicare physician payment cut that began March
has been stopped. After much delay, the Senate passed legislation (HR
4691) that extends the CY 2009 Medicare physician payment level through the end
of March. Senator Jim Bunning (R-KY), who had prevented passage of this measure,
backed down late March 1, allowing passage of the legislation.
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The Interconnectedness of Many Diseases Leads to the Bone Marrow...
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March 1, 2010
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There was a time when we thought we understood disease-damaged tissue. Take for example
diabetic retinopathy, one of the most important causes of visual loss worldwide. In
the case of non-proliferative diabetic retinopathy, we were taught that chronic hyperglycemia
led to vascular changes resulting in retinal injury, ischemia, and acellular retinal capillaries.
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Microvesicles in CLL: A New Form of Tumor and Stromal Cell Communication
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March 1, 2010
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Over the past decade a theme has emerged identifying
the tumor microenvironment as something
essential to preserving leukemia cell survival. This
is particularly true in chronic lymphocytic leukemia (CLL),
where spontaneous apoptosis of tumor cells occurs when
the tumor cells are removed from the microenvironment.
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Setting Sights on a Bad Actor
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March 1, 2010
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Myeloid cell leukemia-1(Mcl-1) protein is a member of the Bcl-2 family of apoptotic regulatory
proteins that is dysregulated in a variety of hematopoietic malignancies, including
multiple myeloma, non-Hodgkin lymphoma, and mantle cell lymphoma.
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